At xyZfish, we have done various pharmacological studies on the behaviour of adult zebrafish. If you are interested in any following paradigms, please contact us. If you have any interests that are not on the list, we can develop them as well.
Pharmacological Treatments With Known Behavioural Effects on Adult Zebrafish
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Behaviour Modulating agent Function/Activity Effect
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Aggression Ethanol GABA-A R modulator Aggression +
Aggression 12a-ethinylestradiol Synthetic oestrogen Aggression -
Antipredation Ethanol GABA-A R modulator Impaired
Anxiety Diazepam Benzodiazepine Anxiety -
Anxiety FG-7142 Benzodiazepine agonist Anxiety +
Anxiety Pentylenetetrazole GABA antagonist Anxiety +
Anxiety Ethanol GABA-A R modulator Anxiety -
Anxiety Buspirone Htr1A partial agonist Anxiety -
Anxiety Alarm sunstance Hypoxanthine-3N- oxide Anxiety +
Anxiety Nicotine NachR agonist Anxiety -
Anxiety Methyllycaconitine Nicotinic antagonist Anxiolytic
Anxiety Dihydro-B-erythroidine Nicotinic antagonist Anxiolytic
Anxiety Mecamylamine Nicotinic antagonist Anxiolytic
Anxiety Morphine Opiate Anxiety -
Anxiety Cocaine(withdrawal) Psychostimulant Anxiety +
Anxiety Fluoxetine 5-HT reuptake inhibitor Anxiety -
Anxiety Caffeine Xanthine alkaloid Anxiety +
Group pref Ethanol GABA-A R modulator Reduced
Learning a-FMH HDAC inhibitor Impair LT
Learning Nicotine NachR agonist Improves
Learning MK-801 NMDA antagonist Impairs memory
Learning L-NAME NO synthase inhibitor Impairs
Light/Dark Ethanol GABA-A R modulator Decrease
Locomotion Ethanol GABA-A R modulator Reduced
Reward Acetylcholine Cholinergic agonist Non-rewarding
Reward Ethanol GABA-A R modulator Rewarding
Reward Nicotine NachR agonist Rewarding
Reward Food Nourishment Rewarding
Reward Morphine Opiate Rewarding
Reward Cocaine Psychostimulant Rewarding
Reward Amphetamine Psychostimulant Rewarding
Sleep Dexmedetomidine a2-adrenoceptor agonist Sedative
Sleep Pentobarbital Barbiturate Hypnotic
Sleep Diazepam Benzodiazepine Hypnotic