At xyZfish, we have done various pharmacological studies on the behaviour of adult zebrafish. If you are interested in any following paradigms, please contact us. If you have any interests that are not on the list, we can develop them as well.

 

 

Pharmacological Treatments With Known Behavioural Effects on Adult Zebrafish

 

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Behaviour     Modulating agent           Function/Activity             Effect

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Aggression        Ethanol                    GABA-A R modulator     Aggression +

 

Aggression       12a-ethinylestradiol   Synthetic oestrogen       Aggression -

 

Antipredation    Ethanol                     GABA-A R modulator      Impaired

 

Anxiety            Diazepam                 Benzodiazepine              Anxiety -

 

Anxiety            FG-7142                   Benzodiazepine agonist   Anxiety +

 

Anxiety            Pentylenetetrazole     GABA antagonist            Anxiety +

 

Anxiety            Ethanol                     GABA-A R modulator      Anxiety -

 

Anxiety            Buspirone                 Htr1A partial agonist       Anxiety -

 

Anxiety            Alarm sunstance      Hypoxanthine-3N- oxide    Anxiety +

 

Anxiety            Nicotine                   NachR agonist                 Anxiety -

 

Anxiety            Methyllycaconitine    Nicotinic antagonist          Anxiolytic

 

Anxiety            Dihydro-B-erythroidine Nicotinic antagonist      Anxiolytic

 

Anxiety            Mecamylamine         Nicotinic antagonist          Anxiolytic

 

Anxiety            Morphine                 Opiate                             Anxiety -

 

Anxiety            Cocaine(withdrawal) Psychostimulant               Anxiety +

 

Anxiety            Fluoxetine             5-HT reuptake inhibitor        Anxiety -

 

Anxiety            Caffeine                  Xanthine alkaloid             Anxiety +

 

Group pref       Ethanol                   GABA-A R modulator         Reduced

 

Learning           a-FMH                    HDAC inhibitor                  Impair LT  

 

Learning           Nicotine                  NachR agonist                  Improves 

 

Learning           MK-801                   NMDA antagonist          Impairs memory

 

Learning           L-NAME                   NO synthase inhibitor       Impairs 

 

Light/Dark        Ethanol                  GABA-A R modulator         Decrease

 

Locomotion       Ethanol                  GABA-A R modulator         Reduced

 

Reward            Acetylcholine          Cholinergic agonist            Non-rewarding

 

Reward            Ethanol                  GABA-A R modulator         Rewarding

 

Reward            Nicotine                 NachR agonist                   Rewarding

 

Reward            Food                      Nourishment                     Rewarding

 

Reward            Morphine                Opiate                             Rewarding

 

Reward            Cocaine                  Psychostimulant               Rewarding

 

Reward            Amphetamine          Psychostimulant               Rewarding

 

Sleep               Dexmedetomidine   a2-adrenoceptor agonist   Sedative

 

Sleep               Pentobarbital           Barbiturate                      Hypnotic

 

Sleep                Diazepam              Benzodiazepine                Hypnotic